c-fos down-regulation inhibits testosterone-dependent male sexual behavior and the associated learning

The Effects of Lead Acetate on Sexual Behavior and the Level of Testosterone in Adult Male Rats

The effects of early isolation on sexual behavior and c-fos expression in naïve male Long-Evans rats.

Previous findings have demonstrated that the maternal environment is important for the development of male sexual behavior. The present study examined the effects of complete early life isolation and replacement 'stroking' stimulation on male sexual behavior and neural activation as seen by Fos immunoreactivity (Fos-IR). Animals were either artificially reared (AR) with minimal (AR-MIN) or maxi...

The effects of gestational and lactational exposure to Nonylphenol on c-jun, and c-fos expression and learning and memory in hippocampus of male F1 rat

Objective(s): To investigate the effects of Nonylphenol (NP) in pups from dams exposed during gestational and lactational periods on immediate early genes (c-jun, c-fos) in hippocampus and the learning and memory of F1 rats. Materials and Methods: Twenty eight pregnant dams, stratified by pregnancy date, were randomly assigned into 4 groups, which were gavaged with NP at the doses of 50 mg/kg/d...

Effect of a null mutation of the c-fos proto-oncogene on sexual behavior of male mice.

Sexual behavior was observed in male mice that were homozygous for a null mutation of the c-fos proto-oncogene, as well as in heterozygous mutants and wild-type controls. The onset of mounting was slower and the subsequent mounting rate was significantly lower in homozygous mutants than in either group of controls. Even so, a similar percentage of males of each genotype achieved ejaculation, an...

Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.

Insulin can stimulate the expression of c-fos and other immediate early genes in many insulin-sensitive cell types. We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA). However, recent studies by other groups have suggested that much of the insuli...